Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion
医学
癌症
癌症研究
肿瘤科
内科学
作者
Sun Young Kim,TaeJin Ahn,Heejin Bang,Jun Soo Ham,Ju-Sun Kim,Seung Tae Kim,Jiryeon Jang,Moonhee Shim,So Young Kang,Se Hoon Park,Byung‐Hoon Min,Hyuk Lee,Won Ki Kang,Kyoung‐Mee Kim,Woong‐Yang Park,Jeeyun Lee
Poor treatment response represents a substantial concern in patients with gastric cancer carrying multiple FGFR2 gene copies. Here, we show the utility of a general FGFR inhibitor for initial response prior to treatment resistance and report the first characterization of a potential resistance mechanism involving an FGFR2-ACSL5 fusion protein.
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