Penetration of 630nm laser and 5-aminolevulinic acid in tissue with intralesional photodynamic therapy

Photodynamic therapy is a common treatment in dermatology for several diseases, its main limitation is the penetration of topical photosensitizer and light in the tissue. However intralesional photodynamic therapy is a new technique where the photosensitizer and sometimes a 630nm laser beam are applied inside the lesión, so it allows achieve deeper penetration. It has been used to treat basal cell carcinoma, hidradenitis suppurativa or keloids.