Effects of PRP and HA injections with intervals on pain and function in knee OA

Aim: The purpose of our study is to evaluate the effects of platelet-rich plasma (PRP), Hyaluronic Acid (HA), and their combination treatments on pain and functional scores in the cases of mild to moderate osteoarthritis.Materials and Methods: One hundred twenty patients receiving PRP and/or HA injection in knee joint space were retrospectively evaluated.The mean age of the patients was 59.5± 5 years.The mean length of follow-up time was 6 months.Twenty-two patients received PRP first and after 15 days they got HA injection while 26 patients received HA first and then PRP 15 days after the first injection.Thirty-three patients were given a single dose of PRP and 39 patients were treated only with HA injection.Patients were then evaluated with WOMAC and VAS scoring systems.Results: A statistical comparison of the groups shows that the HA+PRP group achieved significantly better clinical results.Patients receiving only HA injection had significantly worse clinical outcomes while patients receiving only PRP treatment and PRP+HA had similar results.Discussion: In conclusion, PRP and HA combination appears to be a potentially effective treatment modality in knee osteoarthritis.