Nafion assisted preparation of prussian blue nanoparticles and its application in electrochemical analysis of l-ascorbic acid

Due to the high sensitivity, simplicity and low cost, electrochemistry methods based on nanoparticles have been considered as an attractive technique for l-ascorbic acid. Herein, prussian blue nanoparticles (PBNPs) were synthesized by a fast and convenient synthesis strategy with Nafion and K4[Fe (CN)6] 3H2O. The PBNPs have uniform grain size of about 11.9 nm. PBNPs modified glassy carbon electrode (GCE) was used to construct electrochemical sensor for l-ascorbic acid (AA) detection and the optimization condition was studied. The electrochemical results indicate that PBNPs/GCE sensor shows a linear response to l-ascorbic acid in the range of 1–1100 μM with a detection limit of 0.47 μM and sensitivity of 22.9 μA·mM−1·cm−2 at a working potential of 0.24 V (vs. SCE). The stability and reproducibility of the same PBNPs/GCE are RSD = 0.7% and RSD = 1.3%, respectively. The excellent characteristics of this sensor demonstrates it is a useful tool for accurate determination of l-ascorbic acid in medicine samples such as a vitamin C tablet and for Vitamin C chewable tablets.