生物
抗原
DNA合成
增殖细胞核抗原
致癌物
DNA
分子生物学
细胞培养
细胞生物学
生物化学
免疫学
遗传学
作者
Warren Maltzman,Linda Czyzyk
标识
DOI:10.1128/mcb.4.9.1689-1694.1984
摘要
Elevated levels of the p53 cellular tumor antigen have been previously observed in proliferating and transformed mammalian cells. We found that nontransformed mouse cells treated with either UV light or a UV-mimetic chemical carcinogen exhibited a rapid increase in the amount of p53. This stimulation can be explained, at least in part, on the basis of a post-translational stabilization of p53 which is independent of replicative DNA synthesis, consistent with p53 not being an adventitious product of proliferating cells. The results presented here are interpreted in light of the general hypothesis that p53 is involved in the preparation of mammalian cells for DNA synthesis.
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