化学
废止
氢胺化
芳构化
组合化学
级联
催化作用
基质(水族馆)
亲核细胞
有机化学
色谱法
海洋学
地质学
作者
Louis Yuge,Zifeng Cao,Zhijun Wang,Liang Xu,Wu Yu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-29
卷期号:24 (36): 6554-6559
被引量:7
标识
DOI:10.1021/acs.orglett.2c02522
摘要
Copper-catalyzed cascade cyclization reactions between alkenyl boronic esters and N-H-based nucleophiles have been established, providing new approaches for one-pot assembly of azacycles. Following the Chan-Evans-Lam C-N couplings, the cyclization processes occur via divergent pathways based on the utilized substrates, affording hydroamination product dihydroquinazolin-4-ones or aromatization product quinolines. Via this one-pot C-N coupling/annulation cascade, the target substituted azacycles can be obtained in moderate to good yields in each case.
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