表面等离子共振
电极
材料科学
生物分子
检出限
等离子体子
表面等离子体子
共振(粒子物理)
电化学
化学
光电子学
纳米技术
纳米颗粒
粒子物理学
物理
物理化学
色谱法
作者
Shang Lien Lo,Sheng-Hann Wang,Ting-Wei Chang,Kuang-Li Lee,Ruey-Lin Chern,Pei‐Kuen Wei
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2022-09-12
卷期号:7 (9): 2597-2605
被引量:1
标识
DOI:10.1021/acssensors.2c00850
摘要
We present the use of surface charges in dual gold-nanoslit electrodes to improve the surface plasmon resonance (SPR) detection limit by several orders of magnitude. The SPR is directly generated by gold-nanoslit arrays in the two electrodes. The SPR shifts for both nanoslit arrays are measured simultaneously with a simple hyperspectral setup. When biomolecules are captured by specific antibodies on the dual electrodes, the surface charge is changed during the electrochemical process due to the increase in surface impedance. The push–pull-type electrodes generate opposite surface charges. Using the differences in both spectral shifts, the change in surface charge is detected sensitively. We demonstrate that using a [Fe(CN)6]3–/4– redox process after antigen–antibody interactions, the dual nanoslit electrodes show an enhancement of the detection limit from 1 μg/mL to 10 pg/mL.
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