上皮-间质转换
生物
RNA剪接
肌动蛋白细胞骨架
选择性拼接
细胞生物学
信号转导
细胞迁移
转移
细胞信号
肿瘤进展
转化生长因子
细胞
癌症
癌症研究
细胞骨架
遗传学
基因
核糖核酸
信使核糖核酸
作者
Ying E. Zhang,Christina H. Stuelten
标识
DOI:10.1016/j.semcancer.2024.04.001
摘要
Epithelial to mesenchymal transition (EMT) is a physiological process during development where epithelial cells transform to acquire mesenchymal characteristics, which allows them to migrate and colonize secondary tissues. Many cellular signaling pathways and master transcriptional factors exert a myriad of controls to fine tune this vital process to meet various developmental and physiological needs. Adding to the complexity of this network are post-transcriptional and post-translational regulations. Among them, alternative splicing has been shown to play important roles to drive EMT-associated phenotypic changes, including actin cytoskeleton remodeling, cell-cell junction changes, cell motility and invasiveness. In advanced cancers, transforming growth factor-β (TGF-β) is a major inducer of EMT and is associated with tumor cell metastasis, cancer stem cell self-renewal, and drug resistance. This review aims to provide an overview of recent discoveries regarding alternative splicing events and the involvement of splicing factors in the EMT and TGF-β signaling. It will emphasize the importance of various splicing factors involved in EMT and explore their regulatory mechanisms.
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