内型
特应性皮炎
内表型
表型
疾病
精密医学
医学
临床表型
个性化医疗
生物标志物
生物信息学
免疫学
计算生物学
生物
病理
遗传学
基因
认知
精神科
作者
Chang Ook Park,Su Min Kim,Kwang Hoon Lee,Thomas Bieber
出处
期刊:EBioMedicine
[Elsevier]
日期:2024-05-01
卷期号:103: 105121-105121
标识
DOI:10.1016/j.ebiom.2024.105121
摘要
Atopic dermatitis (AD) is the most common form of chronic skin inflammation with diverse clinical variants. Historically, various AD phenotypes have been grouped together without considering their heterogeneity. This approach has resulted in a lack of phenotype- and endotype-adapted therapeutic strategies. Comprehensive insights into AD pathogenesis have enabled precise medicinal approach for AD. These efforts aimed to redefine the endophenotype of AD and develop various biomarkers for diverse purposes. Among these endeavours, efforts are underway to elucidate the mechanisms (and related biomarkers) that lead to the emergence and progression of atopic diseases originating from AD (e.g., atopic march). This review focuses on diverse AD phenotypes and calls for a definition of endophenotypes. While awaiting scientific validation, these biomarkers ensure predicting disease onset and trajectory and tailoring therapeutic strategies for the future.
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