透视图(图形)
巨噬细胞
生物
计算生物学
细胞生物学
免疫学
癌症研究
计算机科学
遗传学
体外
人工智能
作者
Camille Blériot,Garett Dunsmore,Direna Alonso-Curbelo,Florent Ginhoux
标识
DOI:10.1016/j.ccell.2024.04.002
摘要
Cancer is a progressive disease that can develop and evolve over decades, with inflammation playing a central role at each of its stages, from tumor initiation to metastasis. In this context, macrophages represent well-established bridges reciprocally linking inflammation and cancer via an array of diverse functions that have spurred efforts to classify them into subtypes. Here, we discuss the intertwines between macrophages, inflammation, and cancer with an emphasis on temporal dynamics of macrophage diversity and functions in pre-malignancy and cancer. By instilling temporal dynamism into the more static classic view of tumor-associated macrophage biology, we propose a new framework to better contextualize their significance in the inflammatory processes that precede and result from the onset of cancer and shape its evolution.
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