Serine Promotes Inflammatory Macrophage Polarisation in Periodontitis via NAD + Signalling

AIM: To investigate the role of serine in modulating macrophage polarisation and periodontal inflammation. MATERIALS AND METHODS: /NADH detection were performed to explore the role of serine in periodontitis and the underlying mechanism. RESULTS: levels. Inhibition of intracellular serine transport using L-phenylglycine (L-phg) and mitochondrial complex I (MCI) activity using rotenone reduced inflammatory macrophage polarisation, decreased inflammatory markers and alleviated periodontal tissue damage. CONCLUSION: metabolism may offer new therapeutic strategies for managing periodontitis.