Posttransplant Cyclophosphamide in HLA-matched Peripheral Blood Transplantation: What's next?

The use of post-transplant cyclophosphamide was initially pioneered as a means of permitting haploidentical transplantation across HLA barriers. This approach has now become a standard of care for the prevention of significant acute and chronic GVHD after related and unrelated HLA-matched allogeneic peripheral blood stem cell transplant across a full spectrum of conditioning intensities. This spotlight article discusses recent advances, mechanisms of action, and important unresolved questions in the prevention of GVHD that will help inform new prospective clinical studies.