化学
分子间力
环加成
对映选择合成
催化作用
芳基
反应性(心理学)
酮
磷酸
组合化学
药物化学
立体化学
光化学
有机化学
分子
病理
医学
替代医学
烷基
作者
Yating Dai,Hongchun Huang,Shuangshuang Liang,Yanli Yin,Xu Ban,Xiaowei Zhao,Zhiyong Jiang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-12
卷期号:25 (24): 4551-4555
被引量:7
标识
DOI:10.1021/acs.orglett.3c01585
摘要
An enantioselective intermolecular [3 + 2] cycloaddition of N-arylcyclopropylamines with 2-aryl acrylates/ketones and cyclic ketone-derived terminal olefins via asymmetric photoredox catalysis is reported. A dual catalyst system involving DPZ and a chiral phosphoric acid is effective for the transformations, leading to a wide array of valuable cyclopentylamines with high yields, ee's, and drs. Among them, elaborate modulation of the ester group of 2-aryl acrylates was shown to be effective in improving reactivity, thereby enabling the success of the transformations.
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