医学
一元羧酸盐转运体
内科学
癌症
运输机
肿瘤科
药理学
化学
生物化学
基因
作者
Sarah Halford,Gareth J. Veal,Stephen R. Wedge,Geoffrey S. Payne,Chris M. Bacon,Philip Sloan,I. Dragoni,Kathrin Heinzmann,Sarah Potter,Becky M. Salisbury,Maxime Chénard-Poirier,Alastair Greystoke,Elizabeth Howell,William Innes,Karen Morris,Chris Plummer,Mihaela Rata,George Petrides,Hector C. Keun,Udai Banerji
标识
DOI：10.1158/1078-0432.ccr-22-2263
摘要
Inhibition of monocarboxylate transporter (MCT) 1-mediated lactate transport may have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose-escalation part of a first-in-human trial of AZD3965, a first-in-class MCT1 inhibitor, in advanced cancer.
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