脂肪组织
白色脂肪组织
生物
旁分泌信号
内分泌系统
能量稳态
分泌物
生物信息学
计算生物学
细胞生物学
内分泌学
激素
生物化学
肥胖
受体
作者
Laetitia Coassolo,Niels Banhos Dannieskiold-Samsøe,Meng Zhao,Hobson Allen,Katrin J. Svensson
标识
DOI:10.1016/j.coph.2022.102302
摘要
Adipose tissue is a functional endocrine organ comprised of adipocytes and other cell types that are known to secrete a multiplicity of adipose-derived factors, including lipids and proteins. It is well established that adipose tissue and its secretome can impact systemic energy homeostasis. The endocrine and paracrine effects of adipose-derived factors have been widely studied over the last several decades. Owing to technological advances in genomics and proteomics, several additional adipose-derived protein factors have recently been identified. By learning from previous efforts, the next challenge will be to leverage these discoveries for the prevention or treatment of metabolic disorders. Here, we discuss recently discovered adipose-derived proteins secreted from white or brown adipose tissue and the opportunities and challenges of translating these biological findings into disease therapeutics.
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