Ultrasound-activatable and skin-associated minimally invasive microdevices for smart drug delivery and diagnosis

Ultrasound-activatable and skin-associated minimally invasive microdevices (USMIMs) have garnered significant attention in the domains of smart drug delivery and biomedical diagnosis for on-demand healthcare, owing to their outstanding wearability, flexibility, and comfort. In this review, we present a comprehensive overview of the noteworthy advancements in USMIMs, with a specific focus on device design, potential applications, challenges, and future prospects. The classification of such microdevices primarily encompasses biointerfacing microsystems, including skin-perforable US-assisted microneedles (MNs), skin-attachable sonophoresis and their combination with microbubbles, as well as non-biointerfacing microsystems for drug delivery. Additionally, US-mediated and skin-attached microtransducers utilized in biomedical diagnosis are classified into imaging-related microtransducers, diagramming detection devices, and their combinative systems with applications on diverse signal detection. Besides, the review also highlights the challenges associated with USMIMs, focusing on aspects such as safety, environmental tolerance, wearability/comfortability, and personalization. Furthermore, it offers insights into future perspectives that address these challenges and discuss potential advancements in the field. It is firmly believed that the proposed USMIMs possess immense potential to significantly improve human lives in the near future.