安普克
代谢综合征
AMP活化蛋白激酶
代谢途径
生物
生物化学
内分泌学
糖尿病
新陈代谢
蛋白激酶A
磷酸化
作者
Ye Peng,Zexiu Qi,Yujuan Xu,Feng Xu,Yue Cui,Quancai Sun
出处
期刊:Food Chemistry
[Elsevier]
日期:2024-03-01
卷期号:437: 137784-137784
被引量:1
标识
DOI:10.1016/j.foodchem.2023.137784
摘要
AMPK is a key player in a variety of metabolic and physiological processes, which might be considered one of the most promising targets for both prevention and treatment of metabolic syndrome and its associated diseases. Many dietary components and contaminants have been recently demonstrated to prevent or promote the development these diseases via AMPK-mediated pathways. AMPK can be activated by diverse phytochemical substances such as EGCG, chicoric acid, tomatidine, and others, all of which have been found to contribute to preventing or ameliorating chronic disorders. On the other hand, recent studies have found that metabolic disruptions induced by pesticides such as 1,3-Dichloro-2-propanol, imidacloprid, permethrin, are attributed to the inactivation of AMPK. This review may contribute to the development of functional foods for treatment of metabolic syndrome and associated diseases through modulating AMPK pathway.
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