10B-labelled diboron(4) reagents: Applications and relevance to boron neutron capture therapy

Boron neutron capture therapy (BNCT) is a potentially useful approach to cancer treatment but requires compounds that are enriched in 10B. In this issue of Chem, Liu and co-workers reported a simple and useful approach to the synthesis of a series of 10B-enriched diboron(4) reagents that will greatly facilitate drug discovery in this important field. Boron neutron capture therapy (BNCT) is a potentially useful approach to cancer treatment but requires compounds that are enriched in 10B. In this issue of Chem, Liu and co-workers reported a simple and useful approach to the synthesis of a series of 10B-enriched diboron(4) reagents that will greatly facilitate drug discovery in this important field. Enriched 10B-diboron reagents synthesis from 10BF3Chen et al.ChemJuly 24, 2023In BriefWe present a synthesis of 10B-enriched diboron(4) reagents from the primary source of boron-10, 10BF3. The synthesis of these diboron(4) reagents will not only build up an efficient bridge between inorganic 10B-source and numerous organic 10B-molecules but also benefit boron-related mechanistic studies. Based on the fruitful chemistry of diboron(4) reagents, this chemistry would provide chances for the creation of numerous 10B-enriched molecules for 10B-drug evaluations. It has the potential to accelerate the application of BNCT technology. Full-Text PDF