Diagnostic Value of Serum Glypican-3 Level among Patients with Hepatocellular Carcinoma: A Cross-Sectional Study in BSMMU, Bangladesh

This cross-sectional study was performed in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University. The purpose of this study was to assess the diagnostic value of serum Glypican-3 in detecting hepatocellular carcinoma. It was conducted during January 2015 to December 2016. Through convenience sampling technique, 30 diagnosed patients of hepatocellular carcinoma were enrolled in this study. Mean age was 50.26 ± 14.7 years. Males were the predominant gender in the study, which was 86.7%. Among the 30 respondents, 76.7% had HBsAg positive, 10% had anti HCV antibodies present. Mean serum glypican 3 level was 378.00 ± 168.42 ng/ml. Significant association of Alfa-fetoprotein and serum Glypican 3 in hepatocellular carcinoma patients was found. Serum Alfa-fetoprotein and serum Glypican 3 both were significantly detected in hepatocellular carcinoma but Glypican 3 was more sensitive and specific to detect hepatocellular carcinoma.