Synthesis and Antimicrobial Activity Evaluation of Ammonium Acylhydrazones Based on 4,6-Di-tert-butyl-2,3-dihydroxybenzaldehyde

The condensation reaction of 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde with some ammonium acetohydrazides yielded water-soluble acylhydrazones with different structures of the cationic center. It was shown that in relation to Staphylococcus aureus, Bacillus cereus and Enterococcus faecalis, trimethylammonium chloride derivative exhibits activity at or above the level of comparison drugs, norfloxacin and chloramphenicol, respectively. The resulting compounds do not have a toxic effect on erythrocytes and normal human liver cells. The high activity of diethylmethylammonium acylhydrazone against the formation of biofilms formed by clinical staphylococci strains was shown for the first time. The high efficiency of new compounds in inhibiting the growth of phytopathogens of bacterial and fungal origin was established.