Optimized silicate nanozymes with atomically incorporated iron and manganese for intratumoral coordination-enhanced once-for-all catalytic therapy

A biodegradable SAzymes with Fe/Mn dual atom active sites were massively produced by a facile hydrothermal method. After loading with GA and PEGylation, the innovated FMMPG was used for once-for-all catalytic therapy and magnetic resonance imaging.