伤口愈合
黑色素瘤
转移
血管生成
原发性肿瘤
肿瘤微环境
光动力疗法
细胞迁移
医学
癌症研究
化学
外科
细胞
癌症
内科学
肿瘤细胞
有机化学
生物化学
作者
Shuiling Chen,Yang Luo,Hezhen Yang,Ming Li,Yongjian Liu,Xishen Zhou,Jingguo Hou,Shaobing Zhou
标识
DOI:10.1038/s41467-024-45072-x
摘要
Surgery is the mainstay of treatment modality for malignant melanoma. However, the deteriorative hypoxic microenvironment after surgery is recognized as a stemming cause for tumor recurrence/metastasis and delayed wound healing. Here we design and construct a sprayable therapeutic hydrogel (HIL@Z/P/H) encapsulating tumor-targeted nanodrug and photosynthetic cyanobacteria (PCC 7942) to prevent tumor recurrence/metastasis while promote wound healing. In a postsurgical B16F10 melanoma model in female mice, the nanodrug can disrupt cellular redox homeostasis via the photodynamic therapy-induced cascade reactions within tumor cells. Besides, the photosynthetically generated O2 by PCC 7942 can not only potentiate the oxidative stress-triggered cell death to prevent local recurrence of residual tumor cells, but also block the signaling pathway of hypoxia-inducible factor 1α to inhibit their distant metastasis. Furthermore, the long-lasting O2 supply and PCC 7942-secreted extracellular vesicles can jointly promote angiogenesis and accelerate the wound healing process. Taken together, the developed HIL@Z/P/H capable of preventing tumor recurrence/metastasis while promoting wound healing shows great application potential for postsurgical cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI