热重分析
生物高聚物
傅里叶变换红外光谱
药物输送
复合数
金属有机骨架
化学工程
材料科学
核化学
药品
化学
聚合物
纳米技术
有机化学
复合材料
医学
吸附
药理学
工程类
作者
Hoorieh Djahaniani,Nasim Ghavidel,Hossein Kazemian
标识
DOI:10.1016/j.ijbiomac.2023.124627
摘要
This manuscript describes the synthesis and characterization of a hybrid polymer/HKUST-1 composite for oral drug delivery. A green, one-pot approach was employed to synthesize the modified metal-organic frameworks (MOFs) composite using alkali lignin as a novel pH-responsive biopolymer carrier for the simulated oral delivery system. Several analytical techniques, including Fourier transform infrared (FTIR), X-ray powder diffraction (XRPD), Brunauer-Emmett-Teller (BET), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) were used to analyze the chemical and crystalline structure of HKUST-1 and L/HKUST-1 composite. The drug loading capacity and drug-controlled release behavior of HKUST-1 and L/HKUST-1 were examined using ibuprofen (IBU) as an oral drug model. L/HKUST-1 composite demonstrated a pH-controlled drug release behavior by advancing the drug stability at low pHs such as the gastric medium and controlling drug release in the pH range of 6.8–7.4, similar to intestinal pH. The results suggest that the L/HKUST-1 composite is a promising candidate for oral medication delivery.
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