Evaluation on clinical effects of glucosamine hydrochloride tablets combined with chondroitin sulphate on osteoarthritis of the knee

Objective To evaluate the efficacy of glucosamine hydrochloride tablets combined with chondroitin sulphate in the treatment of gonarthritis. Methods Ninety patients with osteoarthritis of the knee were randomly divided into three group, with 30 patients in each group. Glucosamine hydrochloride (group A), chondroitin sulfate (group B) and glucosamine hydrochloride + chondroitin sulfate (group C) were given orally. The three groups were treated for one month, with seven days as a course of treatment. Patients underwent four courses of treatment. Results Lysholm knee function scores of three groups were improved with the course of treatment. Lysholm knee function score of group C was higher than that of group A and group B at 1 week, 2 weeks and 4 weeks after treatment (P<0.01). Curative efficacy of group C was higher than that of group A and group B, the difference was significant (P<0.05). Conclusions The effect of glucosamine hydrochloride tablets combined with chondroitin sulfate is superior to single glucosamine hydrochloride tablets or chondroitin sulfate in the treatment of osteoarthritis of the knee, which has significant curative effects and is worthy of promotion. Key words: Glucosamine hydrochloride tablets; Chondroitin sulfate; Osteoarthritis of the knee