免疫原性
抗体
药效学
计算生物学
药代动力学
蛋白质工程
计算机科学
医学
药理学
化学
免疫学
生物
生物化学
酶
作者
Bo Wang,Sachith Gallolu Kankanamalage,Jie Dong,Yue Liu
摘要
Abstract In this review, we have summarized the current landscape of therapeutic antibody optimization for successful development. By engineering antibodies with display technology, computer-aided design and site mutagenesis, various properties of the therapeutic antibody candidates can be improved with the purpose of enhancing their safety, efficacy and developability. These properties include antigen binding affinity and specificity, biological efficacy, pharmacokinetics and pharmacodynamics, immunogenicity and physicochemical developability features. A best-in-class strategy may require the optimization of all these properties to generate a good therapeutic antibody.
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