关
电生理学
化学
基础(拓扑)
生物碱
豚鼠
内分泌学
内科学
生物
医学
立体化学
数学
数学分析
古生物学
作者
Hongzhuan Chen,Pei-kun Gu,Lu Zhang,Zheng-jun Jin,Weizhou Chen
出处
期刊:PubMed
日期:1989-09-01
卷期号:10 (5): 399-401
被引量:2
摘要
Guan-fu base A is a new alkaloid first isolated from the tuber of Aconitum coreanum in China. The electrophysiological effects of guan-fu base A were examined on the isolated papillary muscles of guinea pigs by glass-microelectrode technique coupled with microcomputer real-time analysis. Guan-fu base A 50 micrograms/ml had less effect on RP, but markedly decreased Vmax and APA of the fast response action potentials. The action potential duration was shortened at all voltage levels and plateau height was lowered. ERP was prolonged relatively and activation voltage became more negative. The inhibition of guan-fu base A on Vmax showed frequency dependent effects. The above results suggested that guan-fu base A could block the fast Na+ channels and exhibited anti-arrhythmic action.
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