New modified mangosteen(MS) adsorbent was prepared by using thiosemicarbazide and the adsorption behavior of Cd2+ and Pb2+ on mangosteen shell was studied.Results showed that pH 6.0 and shaking time 120 min were the optimal conditions for adsorption of Cd2+ and Pb2+.The adsorption capacity of adsorbent could be greatly improved after modified,with the maximum adsorption capacity of Cd2+ and Pb2+ up to 39.37 and 57.14 mg/g respectively.The adsorption process followed a pseudo-second order equation and the equilibrium isotherm was best described by the Langmuir model rather than the Freundlich model.