Structure of hepatitis B virus core protein and disablement in the hepatitis B antiviral therapy

Core protein which is encoded by the hepatitis B virus(HBV) c gene can package the pre-genome mRNA to form nucleocapsid and play a key role in the HBV replication.The disablement of core protein by RNA interference,core protein antibody and core protein mutant can block capsid formation,inhibit HBV replication.This can be used as a new target for hepatitis B antiviral therapy.