Curative effect of clindamycin assisting azithromycin on 115 cases of infantile mycoplasmal pneumonia

Objective To investigate the effect and the safety of clindamycin assisting azithromycin in the treatment of pediatric mycoplasmal pneumonia.Methods 115 cases of pediatric mycoplasma pneumonia were randomlyd divided into two groups:azithromycin-kitasamycin treatment group(n= 57) and azithromycin-clindamycin treatment group(n=58).In azithromycin-kitasamycin treatment group,azithromycin was given by intravenous drips in the first five days(1/d,10 mg·kg-1·d-1),kitasamycin was given by intravenous drips in the following five days(2 /d,10 mg·kg-1·d-1).In azithromycin-clindamycin treatment group,azithromycin was also given by intravenous drips in the first five days(1 /d,10 mg·kg-1·d-1),clindamycin was given by intravenous drips in the following five days(2 /d,25 mg·kg-1·d-1) by contrast.Results The effect of the azithromycin-clindamycin treatment was better than that of the traditionary azithromycin-kitasamycin treatment,while there was no significant difference in the adverse effect incidence between two groups.Conclusion The effect of clindamycin assisting azithromycinin treatment for the pediatric mycoplasma pneumonia is better than that of the traditionary macrolide antibiotics azithromycin-kitasamycin treatment and suggested to use in the treatment for mycoplasma pneumonia.