Objective To assess the combined application of staged enteral and parenteral nutrition support in patients with acute pancreatitis. Methods Sixty patients with acute pancreatitis who underwent conservative treatment were divided into total parenteral nutrition and staged parenteral and enteral nutrition. The changes of clinical indicators and clinical outcome were recorded. Results All of the 30 cases in the total parenteral nutrition+enteral nutrition group tolerated the enteral nutrition.One week after nutrition support from parenteral nutrition to enteral nutrition, total protein serum albumin and blood calcium significantly increased (P0.01);ALT and AST significantly decreased (P0.01).The blood glucose was significantly decreased (P0.05).The average hospital stay was shorter in the total parenteral nutrition+enteral nutrition group than in the total parenteral nutrition group(P0.05),and the average charge and total charge were cheaper in the total parenteral nutrition+enteral nutrition group than in the total parenteral nutrition group.Conclusion The results of glucose and nutritional indicators in total parenteral nutrition and enteral nutrition are better than in total parenteral nutrition group.