Objective To study the therapeutic effects of microendoscopic discectomy with smallincision fenestration discectomy for lumbar disc herniation.Methods The clinical data of 68 patients who underwent lumbar disc herniation in Taihe Hospital Affiliated to Hubei University of Medicine during April 2010 and April 2011 were collected,and randomly divided into observation group and control group,34 cases in each group.The observation group was treated with small-incision fenestration discectomy,the control group were treated with microendoscopic discectomy.The clinical efficacy of the two groups was observed.Results The VAS and ODI in both groups were reduced significantly after operation(P 0.05) and there were no significant differences between the two groups(P 0.05).The operating time of the observation group was shorter and blood loss was more than those of the control group(P 0.05).Conclusion Microendoscopic discectomy and small-incision fenestration discectomy both have own advantages and disadvantages for lumbar disc herniation with similar therapeutic effect,and the optimal solution can be chosen according to the particular situation.