生物
种质资源
生物强化
等位基因
基因座(遗传学)
数量性状位点
遗传变异
扎梅斯
回交
遗传学
类胡萝卜素
农学
微量营养素
基因
植物
有机化学
化学
作者
Jianbing Yan,Catherine B. Kandianis,Carlos Harjes,Longchuan Bai,Eun Ha Kim,Xiaohong Yang,Debra J. Skinner,Zhiyuan Fu,Sharon E. Mitchell,Qing Li,Maria G. Salas Fernandez,M. Zaharieva,Raman Babu,Yang Fu,Natalia Palacios,Jiansheng Li,Dean DellaPenna,Thomas P. Brutnell,Edward S. Buckler,Marilyn L. Warburton,Torbert Rocheford
出处
期刊:Nature Genetics
[Springer Nature]
日期:2010-03-21
卷期号:42 (4): 322-327
被引量:419
摘要
Breeding to increase beta-carotene levels in cereal grains, termed provitamin A biofortification, is an economical approach to address dietary vitamin A deficiency in the developing world. Experimental evidence from association and linkage populations in maize (Zea mays L.) demonstrate that the gene encoding beta-carotene hydroxylase 1 (crtRB1) underlies a principal quantitative trait locus associated with beta-carotene concentration and conversion in maize kernels. crtRB1 alleles associated with reduced transcript expression correlate with higher beta-carotene concentrations. Genetic variation at crtRB1 also affects hydroxylation efficiency among encoded allozymes, as observed by resultant carotenoid profiles in recombinant expression assays. The most favorable crtRB1 alleles, rare in frequency and unique to temperate germplasm, are being introgressed via inexpensive PCR marker-assisted selection into tropical maize germplasm adapted to developing countries, where it is most needed for human health.
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