缺氧诱导因子
转录因子
转录调控
缺氧(环境)
抄写(语言学)
生物
细胞生物学
缺氧诱导因子1
核糖核酸
基因表达调控
遗传学
基因
化学
氧气
语言学
哲学
有机化学
作者
Veronica L. Dengler,Matthew D. Galbraith,Joaquín M. Espinosa
标识
DOI:10.3109/10409238.2013.838205
摘要
The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
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