整合素
细胞生物学
粘附
血管生成
化学
生长因子
细胞粘附
伤口愈合
血管生成素
血管内皮生长因子
生物
癌症研究
免疫学
受体
生物化学
血管内皮生长因子受体
有机化学
作者
Yueqing Zhang,Xiaobo Hu,Rui-Yang Tian,Wan-gui Wei,Wei Hu,Xia Chen,Wei Han,Huayou Chen,Yi Gong
标识
DOI:10.1016/j.bbrc.2006.06.053
摘要
Angiopoietin-related growth factor (AGF) is a newly identified member of angiopoietin-related proteins (ARPs)/angiopoietin-like proteins (Angptls). AGF has been considered as a novel growth factor in accelerating cutaneous wound healing, as it is capable of stimulating keratinocytes proliferation as well as angiogenesis. But in our paper, we demonstrate that AGF stimulates keratinocytes proliferation only at high protein concentration, however, it can potently promote adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells. Furthermore, we confirm that the adhesion and migration cellular events are mediated by RGD-binding integrins, most possibly the alpha(v)-containing integrins, by in vitro inhibition assays using synthetic competitive peptides. Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism.
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