P1‐082: Correlation between white matter lesions progression and cognitive decline in patients with Alzheimer's disease, mixed dementia, vascular dementia and normal elderly persons in prospective study

White matter lesions (WML) are common finding in normal elderly subjects but also in patients with dementia. There is still no sufficient agreement how does WML impact the cognition mainly in normal elderly subject and patients with Alzheimer's disease, though is accepted that progression of WML worsens the cognitive decline. In order to throw a light in this area we carried out our study. 20 patients with Alzheimer's disease, 21 patients with mixed dementia, 20 patients with vascular dementia and 20 normal elderly persons were enrolled in our study. All 81 persons were examined with psychometric test battery (MMSE, ADAS-Cog,) and MRI of the brain was done in the start of the study and after two years. WML have been assessed through ARWMC rating scale (Wahlund et al., 2001). MMS decline in two years was 5,1 in the patients with Alzheimer's disease, 3,09 in patients with mixed dementia, 2,70 in patients with vascular dementia and 0,9 in normal elderly persons. Progression of ARWMC score was 1,0 in the patients with Alzheimer's disease, 2,27 in patients with mixed dementia, 3,2 in patients with vascular dementia and 0,6 in normal elderly persons. Our examination has shown that patients with “pure”Alzheimer's disease had faster progression of cognitive deficit than patients with mixed and vascular dementia. Moreover these patients had significant less amount of WML in MRI compared with other groups as well as the progression of WML was significant less in this group.