狂犬病病毒
生物
病毒
病毒学
绿色荧光蛋白
狂犬病
突变体
轴浆运输
细胞生物学
基因
遗传学
作者
Ian R. Wickersham,Stefan Finke,Karl‐Klaus Conzelmann,Edward M. Callaway
出处
期刊:Nature Methods
[Springer Nature]
日期:2006-12-10
卷期号:4 (1): 47-49
被引量:595
摘要
We have constructed a deletion-mutant rabies virus encoding EGFP and find it to be an excellent tool for studying detailed morphology and physiology of neurons projecting to injection sites within the mammalian brain. The virus cannot spread beyond initially infected cells yet, unlike other viral vectors, replicates its core within them. The cells therefore fluoresce intensely, revealing fine dendritic and axonal structure with no background from partially or faintly labeled cells.
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