双性恋
生物
遗传学
同步
基因
河豚
基因簇
同源(生物学)
基因组
RNA剪接
核糖核酸
作者
Bodo Brunner,Ute Hornung,Zhihong Shan,Indrajit Nanda,Mariko Kondo,Enchshargal Zend-Ajusch,Thomas Haaf,Hans‐Hilger Ropers,Akihiro Shima,Michael Schmid,Vera M. Kalscheuer,Manfred Schartl
出处
期刊:Genomics
[Elsevier]
日期:2001-09-01
卷期号:77 (1-2): 8-17
被引量:136
标识
DOI:10.1006/geno.2001.6615
摘要
Genes related to the Drosophila melanogaster doublesex and Caenorhabditis elegans mab-3 genes are conserved in human. They are identified by a DNA-binding homology motif, the DM domain, and constitute a gene family (DMRTs). Unlike the invertebrate genes, whose role in the sex-determination process is essentially understood, the function of the different vertebrate DMRT genes is not as clear. Evidence has accumulated for the involvement of DMRT1 in male sex determination and differentiation. DMRT2 (known as terra in zebrafish) seems to be a critical factor for somitogenesis. To contribute to a better understanding of the function of this important gene family, we have analyzed DMRT1, DMRT2, and DMRT3 from the genome model organism Fugu rubripes and the medakafish, a complementary model organism for genetics and functional studies. We found conservation of synteny of human chromosome 9 in F. rubripes and an identical gene cluster organization of the DMRTs in both fish. Although expression analysis and gene linkage mapping in medaka exclude a function for any of the three genes in the primary step of male sex determination, comparison of F. rubripes and human sequences uncovered three putative regulatory regions that might have a role in more downstream events of sex determination and human XY sex reversal.
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