Protective role of biological potential curcumin in epileptic seizures and memory impairment

Central nervous system disorders are of great concern due to increasing stress and changing living conditions. Epilepsy is one of the most prevalent CNS disorders, and as a number of side eff ects are associated with the present antiepileptic drug treatments. The effect of curcumin on epileptic seizures, together with its effect on memory retention and the role of monoamines in protection from seizures and memory impairment. The estimations of norepinephrine, dopamine and serotonin in cerebral cortex, cerebellum, hippocampus, pons and hypothalamus made it evident that curcumin exerted a potential antiepileptic and memory retentive effects, with considerable influence on the brain monoamine levels.