麻风分枝杆菌
肺结核
结核分枝杆菌
dna疫苗
麻风病
接种疫苗
抗原
病毒学
免疫学
微生物学
医学
生物
免疫
病理
作者
Paul Roche,Kapil Dev Neupane,S. S. Failbus,Arun T. Kamath,Warwick J. Britton
出处
期刊:PubMed
日期:2001-06-01
卷期号:69 (2): 93-8
被引量:6
摘要
A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.
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