Objective To explore the correlation between malnutrition of patient with ischemic stroke and poor prognosis.Methods In 82 patients(46 males and 36 females) with acute ischemic stroke admitted to this hospital,nutritional indexes on the 1st day and (14 ± 1) th day were compared between different sexes and prognosis-related influential factors were analyzed.Results The incidence of malnutrition on the first day after admission was 18.29%,while that on (14 ± 1) th day was 30.49% (P 0.05).Three nutrition indexes including brachial triceps skinfold thickness (TSF),upper-arm muscle circumference(UAMC) and serum albumin(ALB) of the patients on the (14 ± 1) th day after admission decreased significantly compared with those on the 1st day (P 0.05,P 0.01).TSF and ALB decreased more significantly in males than in females,however, UAMC decreased more significantly in females than in males (P 0.01).Logistic regression analysis found that age on admission (P = 0.009),hyperglycemia on admission (P = 0.038),NIHSS score (P = 0.001) and malnutrition on admission (P = 0.018) were the risk factors for 3-month poor prognosis.Age on adimission was significantly positively correlated with hyperglycemia,and negatively correlated with NIHSS score.Conclusion Nutritional status after ischemic stroke shows a worsening trend.Malnutrition on admission is an independent risk factor for 3-month poor prognosis.