Comparative study on purification of berberine in rhizoma of Coptis chinensis Franch by different ways

Objective:To compare the purification effects of berberine in rhizoma of Coptis chinensis Franch by the liquid-liquid extraction and the macroporous adsorption resin to offer reference for its development and utilization.Methods:The macroporous adsorption resin and the liquid-liquid extraction were used to extract berberine.Results:Using berberine hydrochloride as control,the macroporous adsorption resin was higher than the liquid-liquid extraction in terms of the product weight and the content of berberine in product.The D101 macroporous adsorption resin had a good effect on the purification of berberine in rhizoma of Coptis chinensis Franch and the content of berberine in product reached to 29.82%.Conclusion:Berberine as the main component of traditional Chinese medicinal material rhizoma of Coptis chinensis Franch demonstrates better effects in antibiosis,diminishing inflammation and treating cardiovascular diseases,which possesses extensive application prospects.