RNAi mechanism and application

RNAi means gene silencing triggered by double-stranded RNA. Through the study of flies, bugs, fungi and plants, the mechanism of RNAi has been confirmed. The key player in RNAi is small interference RNA(siRNA) generated by Dicer. Now more and more evidences show that application of RNAi plays an important role in biotechnology and will be useful for treating human genetic disease.