Type I Protein Arginine Methyltransferases Overexpression Promotes Transformation and Potentiates Her2/Neu–Driven Tumorigenesis

Abstract Bao and colleagues demonstrate that type I protein arginine methyltransferases (PRMT) are directly involved in mammary gland transformation and tumor progression. Notably, several distinct phenotypes require further investigation such as PRMT1/CARM1–induced transformation, CARM1-mediated delay in tumorigenesis, and PRMTs potentiation of Her2-dependent tumors. The PRMT overexpression transgenic mouse models should encourage and facilitate further mechanistic interrogation and the development of PRMT-directed therapies. See related article by Bao et al., p. 21