子宫内膜癌
亚型
浆液性液体
医学
疾病
肿瘤科
内科学
入射(几何)
癌
清除单元格
癌症
妇科
计算机科学
光学
物理
程序设计语言
作者
Mary Ellen Urick,Daphne W. Bell
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2019-08-06
卷期号:19 (9): 510-521
被引量:245
标识
DOI:10.1038/s41568-019-0177-x
摘要
Endometrial cancer accounts for ~76,000 deaths among women each year worldwide. Disease mortality and the increasing number of new diagnoses make endometrial cancer an important consideration in women's health, particularly in industrialized countries, where the incidence of this tumour type is highest. Most endometrial cancers are carcinomas, with the remainder being sarcomas. Endometrial carcinomas can be classified into several histological subtypes, including endometrioid, serous and clear cell carcinomas. Histological subtyping is currently used routinely to guide prognosis and treatment decisions for endometrial cancer patients, while ongoing studies are evaluating the potential clinical utility of molecular subtyping. In this Review, we summarize the overarching molecular features of endometrial cancers and highlight recent studies assessing the potential clinical utility of specific molecular features for early detection, disease risk stratification and directing targeted therapies.
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