蛋白酶体
癌症研究
癌症
化学
癌细胞
蛋白酶体抑制剂
医学
细胞生物学
生物
氧化应激
蛋白质降解
氧化还原
细胞凋亡
泛素
活性氧
作者
Gulce Sari,Zehra Okat,Ali Sahin,Betul Karademir
标识
DOI:10.2174/1381612825666190201120013
摘要
Redox homeostasis is important for the maintenance of cell survival. Under physiological conditions, redox system works in a balance and involves activation of many signaling molecules. Regulation of redox balance via signaling molecules is achieved by different pathways and proteasomal system is a key pathway in this process. Importance of proteasomal system on signaling pathways has been investigated for many years. In this direction, many proteasome targeting molecules have been developed. Some of them are already in the clinic for cancer treatment and some are still under investigation to highlight underlying mechanisms. Although there are many studies done, molecular mechanisms of proteasome inhibitors and related signaling pathways need more detailed explanations. This review aims to discuss redox status and proteasomal system related signaling pathways. In addition, cancer therapies targeting proteasomal system and their effects on redox-related pathways have been summarized.
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