骨髓
祖细胞
免疫学
生物
粒细胞
癌症研究
流式细胞术
干细胞
细胞生物学
作者
Yanfang Peipei Zhu,Lindsey E. Padgett,Huy Q. Dinh,Paola Marcovecchio,Amy Blatchley,Runpei Wu,Erik Ehinger,Cheryl Kim,Zbigniew Mikulski,Grégory Seumois,Ariel Madrigal,Pandurangan Vijayanand,Catherine C. Hedrick
出处
期刊:Cell Reports
[Elsevier]
日期:2018-08-01
卷期号:24 (9): 2329-2341.e8
被引量:157
标识
DOI:10.1016/j.celrep.2018.07.097
摘要
Neutrophils are short-lived cells that play important roles in both health and disease. Neutrophils and monocytes originate from the granulocyte monocyte progenitor (GMP) in bone marrow; however, unipotent neutrophil progenitors are not well defined. Here, we use cytometry by time of flight (CyTOF) and single-cell RNA sequencing (scRNA-seq) methodologies to identify a committed unipotent early-stage neutrophil progenitor (NeP) in adult mouse bone marrow. Importantly, we found a similar unipotent NeP (hNeP) in human bone marrow. Both NeP and hNeP generate only neutrophils. NeP and hNeP both significantly increase tumor growth when transferred into murine cancer models, including a humanized mouse model. hNeP are present in the blood of treatment-naive melanoma patients but not of healthy subjects. hNeP can be readily identified by flow cytometry and could be used as a biomarker for early cancer discovery. Understanding the biology of hNeP should allow the development of new therapeutic targets for neutrophil-related diseases, including cancer.
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