MicroRNA-340-5p suppresses osteosarcoma development by down-regulating the Wnt/β-catenin signaling pathway via targeting the STAT3 gene.

Low expression of miR-340-5p in OS and U2OS cells could inhibit the course of OS by negatively regulating Wnt/β-catenin signaling pathway through targeting STAT3 gene. Therefore, miR-340-5p might be a potential biomarker and target for the diagnosis and treatment of OS.