医学
心脏病学
心肌梗塞
血栓
血栓形成
内科学
左心室血栓
心内注射
血瘀
肝素
冲程(发动机)
重症监护医学
病理
中医药
机械工程
替代医学
工程类
作者
Mauro Massussi,Andrea Scotti,Gregory Y. H. Lip,Riccardo Proietti
出处
期刊:European Heart Journal - Cardiovascular Pharmacotherapy
[Oxford University Press]
日期:2020-06-22
卷期号:7 (2): 158-167
被引量:47
标识
DOI:10.1093/ehjcvp/pvaa066
摘要
Left ventricular thrombosis (LVT) is a major risk factor for systemic thromboembolism and might complicate both the acute and the chronic phase of ischaemic heart disease after myocardial infarction and, less frequently, non-ischaemic cardiomyopathies. The pathophysiology of thrombus formation is complex and involves the three aspects of Virchow's triad: blood stasis, prothrombotic state, and tissue injury. Advances in technology have improved the detection rate of intracardiac thrombi, but several uncertainties still remain regarding the optimal treatment strategy within daily clinical practice. Of note, anticoagulation therapy with heparin and vitamin K antagonists decreases the risk of embolic stroke though exposing patients to an undeniable risk of bleeding complications. Although limited data on the off-label use of direct oral anticoagulants have reported safety and efficacy for LVT resolution, yet more evidence is needed to justify their use in clinical practice.
科研通智能强力驱动
Strongly Powered by AbleSci AI