Artemisia annua is an annual herb, which is a traditional Chinese medicine in China. The high water soluble artemisinin derivative extracted from Artemisia annua is Artemisia annua water extract. In this experiment, the modeling method is used, and the Artemisia annua water extract is used alone or in combination with other lipid-lowering drugs. Finally, the results showed that the effect of the combination of drugs was better than that of Artemisia annua water extract alone, and the effect of the drug ratio of 1:1 was the best. It can significantly reduce the content of triglyceride in serum and cholesterol, increase the ratio of H/L, and show a good synergistic effect.