化学
芳基
镍
催化作用
位阻效应
磷化氢
分子
氮气
组合化学
有机化学
烷基
作者
Han Li,Jie Sheng,Guang‐Xu Liao,Bingbing Wu,Hui‐Qi Ni,Yan Li,Xisheng Wang
标识
DOI:10.1002/adsc.202000985
摘要
Abstract A nickel‐catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF 3 CH 2 I has been developed, demonstrating high efficiency, excellent functional‐group compatibility, especially with large sterically hindered groups. The key to success is the combination of nickel with readily available nitrogen and phosphine ligands. The powerful potential of this strategy is further demonstrated by the late‐stage modification of several derived bioactive molecules. magnified image
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